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Experimental Pharmacogenetics

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eBook details

  • Title: Experimental Pharmacogenetics
  • Author : Hans Meier
  • Release Date : January 02, 2012
  • Genre: Engineering,Books,Professional & Technical,
  • Pages : * pages
  • Size : 2031 KB

Description

A certain interdependence of drug action and heredity has long been recognized through the experiences of workers studying the genetics of bacteria, of human geneticists classifying man according to pharmacologic assays (e.g., taste), and of cytologists observing drugs that influence heredity. However, it was only because research in the broad aspects of pharmacology and genetics has been rapidly expanding in recent years, and by focusing greater attention on biochemical aspects, that a link has been established between the two disciplines. As a result a new science, termed "pharmacogenetics," has evolved. Pharmacogenetics is defined as the study in animal species of genetically determined variations that are revealed by the effects of drugs (Motulsky, 1958; Vogel, 1959). Since the total variation in the response to drugs is caused by both hereditary and non-hereditary forces, pharmacogenetics deals only with part of the modifying factors of drug action.


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